The HIV-2 p24, Capsid Protein (Human Immunodeficiency Virus-2) Antibody from MyBioSource.com is a Mouse Monoclonal antibody to HIV p24. The HIV-2 p24, Capsid Protein (Human Immunodeficiency Virus-2) Antibody has been validated for the following applications: Immunofluorescence, Immunoprecipitation, and Western Blot.
Description
Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Structural studies demonstrated two distinct domains (N and C-terminal domains) that have different roles in the virus morphogenesis. Additionally, the level of p24 found in the blood serum is used as an indicator of HIV progression. HIV-1 performs highly complex orchestrated tasks during the assembly, budding, maturation and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA